Pulsed-dose-rate peri-operative brachytherapy as an interstitial boost in organ-sparing treatment of breast cancer
Identifieur interne : 000C13 ( Main/Exploration ); précédent : 000C12; suivant : 000C14Pulsed-dose-rate peri-operative brachytherapy as an interstitial boost in organ-sparing treatment of breast cancer
Auteurs : Krystyna Serkies ; Janusz Ja Kiewicz [Pologne] ; Rafał Dziadziuszko ; Jacek JassemSource :
- Journal of Contemporary Brachytherapy [ 1689-832X ] ; 2016.
Abstract
To evaluate peri-operative multicatheter interstitial pulsed-dose-rate brachytherapy (PDR-BT) with an intra-operative catheter placement to boost the tumor excision site in breast cancer patients treated conservatively.
Between May 2002 and October 2008, 96 consecutive T1-3N0-2M0 breast cancer patients underwent breast-conserving therapy (BCT) including peri-operative PDR-BT boost, followed by whole breast external beam radiotherapy (WBRT). The BT dose of 15 Gy (1 Gy/pulse/h) was given on the following day after surgery.
No increased bleeding or delayed wound healing related to the implants were observed. The only side effects included one case of temporary peri-operative breast infection and 3 cases of fat necrosis, both early and late. In 11 patients (11.4%), subsequent WBRT was omitted owing to the final pathology findings. These included eight patients who underwent mastectomy due to multiple adverse prognostic pathological features, one case of lobular carcinoma
Peri-operative PDR-BT boost with intra-operative tube placement followed by EBRT is feasible and devoid of considerable toxicity, and provides excellent long-term local control. However, this strategy necessitates careful patient selection and histological confirmation of primary diagnosis.
Url:
DOI: 10.5114/jcb.2016.64512
PubMed: 28115954
PubMed Central: 5241379
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 004050
- to stream Pmc, to step Curation: 004049
- to stream Pmc, to step Checkpoint: 000658
- to stream Ncbi, to step Merge: 008C44
- to stream Ncbi, to step Curation: 008C44
- to stream Ncbi, to step Checkpoint: 008C44
- to stream Main, to step Merge: 000C14
- to stream Main, to step Curation: 000C13
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pulsed-dose-rate peri-operative brachytherapy as an interstitial boost in organ-sparing treatment of breast cancer</title>
<author><name sortKey="Serkies, Krystyna" sort="Serkies, Krystyna" uniqKey="Serkies K" first="Krystyna" last="Serkies">Krystyna Serkies</name>
<affiliation><nlm:aff id="aff0001">Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk</nlm:aff>
<wicri:noCountry code="subfield">Gdańsk</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ja Kiewicz, Janusz" sort="Ja Kiewicz, Janusz" uniqKey="Ja Kiewicz J" first="Janusz" last="Ja Kiewicz">Janusz Ja Kiewicz</name>
<affiliation wicri:level="1"><nlm:aff id="aff0002">Department of Plastic Surgery, Medical University of Gdańsk, Gdańsk, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Plastic Surgery, Medical University of Gdańsk, Gdańsk</wicri:regionArea>
<wicri:noRegion>Gdańsk</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dziadziuszko, Rafal" sort="Dziadziuszko, Rafal" uniqKey="Dziadziuszko R" first="Rafał" last="Dziadziuszko">Rafał Dziadziuszko</name>
<affiliation><nlm:aff id="aff0001">Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk</nlm:aff>
<wicri:noCountry code="subfield">Gdańsk</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jassem, Jacek" sort="Jassem, Jacek" uniqKey="Jassem J" first="Jacek" last="Jassem">Jacek Jassem</name>
<affiliation><nlm:aff id="aff0001">Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk</nlm:aff>
<wicri:noCountry code="subfield">Gdańsk</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">28115954</idno>
<idno type="pmc">5241379</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241379</idno>
<idno type="RBID">PMC:5241379</idno>
<idno type="doi">10.5114/jcb.2016.64512</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">004050</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004050</idno>
<idno type="wicri:Area/Pmc/Curation">004049</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004049</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000658</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000658</idno>
<idno type="wicri:Area/Ncbi/Merge">008C44</idno>
<idno type="wicri:Area/Ncbi/Curation">008C44</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">008C44</idno>
<idno type="wicri:doubleKey">1689-832X:2016:Serkies K:pulsed:dose:rate</idno>
<idno type="wicri:Area/Main/Merge">000C14</idno>
<idno type="wicri:Area/Main/Curation">000C13</idno>
<idno type="wicri:Area/Main/Exploration">000C13</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pulsed-dose-rate peri-operative brachytherapy as an interstitial boost in organ-sparing treatment of breast cancer</title>
<author><name sortKey="Serkies, Krystyna" sort="Serkies, Krystyna" uniqKey="Serkies K" first="Krystyna" last="Serkies">Krystyna Serkies</name>
<affiliation><nlm:aff id="aff0001">Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk</nlm:aff>
<wicri:noCountry code="subfield">Gdańsk</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ja Kiewicz, Janusz" sort="Ja Kiewicz, Janusz" uniqKey="Ja Kiewicz J" first="Janusz" last="Ja Kiewicz">Janusz Ja Kiewicz</name>
<affiliation wicri:level="1"><nlm:aff id="aff0002">Department of Plastic Surgery, Medical University of Gdańsk, Gdańsk, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Plastic Surgery, Medical University of Gdańsk, Gdańsk</wicri:regionArea>
<wicri:noRegion>Gdańsk</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dziadziuszko, Rafal" sort="Dziadziuszko, Rafal" uniqKey="Dziadziuszko R" first="Rafał" last="Dziadziuszko">Rafał Dziadziuszko</name>
<affiliation><nlm:aff id="aff0001">Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk</nlm:aff>
<wicri:noCountry code="subfield">Gdańsk</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jassem, Jacek" sort="Jassem, Jacek" uniqKey="Jassem J" first="Jacek" last="Jassem">Jacek Jassem</name>
<affiliation><nlm:aff id="aff0001">Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk</nlm:aff>
<wicri:noCountry code="subfield">Gdańsk</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Contemporary Brachytherapy</title>
<idno type="ISSN">1689-832X</idno>
<idno type="eISSN">2081-2841</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="s1"><title>Purpose</title>
<p>To evaluate peri-operative multicatheter interstitial pulsed-dose-rate brachytherapy (PDR-BT) with an intra-operative catheter placement to boost the tumor excision site in breast cancer patients treated conservatively.</p>
</sec>
<sec id="s2"><title>Material and methods</title>
<p>Between May 2002 and October 2008, 96 consecutive T1-3N0-2M0 breast cancer patients underwent breast-conserving therapy (BCT) including peri-operative PDR-BT boost, followed by whole breast external beam radiotherapy (WBRT). The BT dose of 15 Gy (1 Gy/pulse/h) was given on the following day after surgery.</p>
</sec>
<sec id="s3"><title>Results</title>
<p>No increased bleeding or delayed wound healing related to the implants were observed. The only side effects included one case of temporary peri-operative breast infection and 3 cases of fat necrosis, both early and late. In 11 patients (11.4%), subsequent WBRT was omitted owing to the final pathology findings. These included eight patients who underwent mastectomy due to multiple adverse prognostic pathological features, one case of lobular carcinoma <italic>in situ</italic>
, and two cases with no malignant tumor. With a median follow-up of 12 years (range: 7-14 years), among 85 patients who completed BCT, there was one ipsilateral breast tumor and one locoregional nodal recurrence. Six patients developed distant metastases and one was diagnosed with angiosarcoma within irradiated breast. The actuarial 5- and 10-year disease free survival was 90% (95% CI: 84-96%) and 87% (95% CI: 80-94%), respectively, for the patients with invasive breast cancer, and 91% (95% CI: 84-97%) and 89% (95% CI: 82-96%), respectively, for patients who completed BCT. Good cosmetic outcome by self-assessment was achieved in 58 out of 64 (91%) evaluable patients.</p>
</sec>
<sec id="s4"><title>Conclusions</title>
<p>Peri-operative PDR-BT boost with intra-operative tube placement followed by EBRT is feasible and devoid of considerable toxicity, and provides excellent long-term local control. However, this strategy necessitates careful patient selection and histological confirmation of primary diagnosis.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bartelink, H" uniqKey="Bartelink H">H Bartelink</name>
</author>
<author><name sortKey="Horiot, Jc" uniqKey="Horiot J">JC Horiot</name>
</author>
<author><name sortKey="Poortmans, P" uniqKey="Poortmans P">P Poortmans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartelink, H" uniqKey="Bartelink H">H Bartelink</name>
</author>
<author><name sortKey="Maingon, P" uniqKey="Maingon P">P Maingon</name>
</author>
<author><name sortKey="Poortmans, P" uniqKey="Poortmans P">P Poortmans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frazier, Rc" uniqKey="Frazier R">RC Frazier</name>
</author>
<author><name sortKey="Kestin, Ll" uniqKey="Kestin L">LL Kestin</name>
</author>
<author><name sortKey="Kini, V" uniqKey="Kini V">V Kini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fritz, P" uniqKey="Fritz P">P Fritz</name>
</author>
<author><name sortKey="Berns, C" uniqKey="Berns C">C Berns</name>
</author>
<author><name sortKey="Anton, Hw" uniqKey="Anton H">HW Anton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harms, W" uniqKey="Harms W">W Harms</name>
</author>
<author><name sortKey="Krempien, R" uniqKey="Krempien R">R Krempien</name>
</author>
<author><name sortKey="Hensley, Fw" uniqKey="Hensley F">FW Hensley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krishnan, Ec" uniqKey="Krishnan E">EC Krishnan</name>
</author>
<author><name sortKey="Krishnan, L" uniqKey="Krishnan L">L Krishnan</name>
</author>
<author><name sortKey="Cytaki, Ep" uniqKey="Cytaki E">EP Cytaki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Manning, Ma" uniqKey="Manning M">MA Manning</name>
</author>
<author><name sortKey="Arthur, Dw" uniqKey="Arthur D">DW Arthur</name>
</author>
<author><name sortKey="Schmidt Ullrich, Rk" uniqKey="Schmidt Ullrich R">RK Schmidt-Ullrich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bedwinek, J" uniqKey="Bedwinek J">J Bedwinek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Debiose, Da" uniqKey="Debiose D">DA DeBiose</name>
</author>
<author><name sortKey="Horwitz, Em" uniqKey="Horwitz E">EM Horwitz</name>
</author>
<author><name sortKey="Martinez, Aa" uniqKey="Martinez A">AA Martinez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Regine, Wf" uniqKey="Regine W">WF Regine</name>
</author>
<author><name sortKey="Ayyangar, Km" uniqKey="Ayyangar K">KM Ayyangar</name>
</author>
<author><name sortKey="Komarnicky, Lt" uniqKey="Komarnicky L">LT Komarnicky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Serkies, K" uniqKey="Serkies K">K Serkies</name>
</author>
<author><name sortKey="Tarnawska, Z" uniqKey="Tarnawska Z">Z Tarnawska</name>
</author>
<author><name sortKey="Blukis, A" uniqKey="Blukis A">A Blukis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mansfield, Cm" uniqKey="Mansfield C">CM Mansfield</name>
</author>
<author><name sortKey="Komarnicky, La" uniqKey="Komarnicky L">LA Komarnicky</name>
</author>
<author><name sortKey="Schwartz, Gf" uniqKey="Schwartz G">GF Schwartz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reitsamer, R" uniqKey="Reitsamer R">R Reitsamer</name>
</author>
<author><name sortKey="Peintinger, F" uniqKey="Peintinger F">F Peintinger</name>
</author>
<author><name sortKey="Sedlmayer, F" uniqKey="Sedlmayer F">F Sedlmayer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vaidya, Js" uniqKey="Vaidya J">JS Vaidya</name>
</author>
<author><name sortKey="Baum, M" uniqKey="Baum M">M Baum</name>
</author>
<author><name sortKey="Tobias, Js" uniqKey="Tobias J">JS Tobias</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Veronesi, U" uniqKey="Veronesi U">U Veronesi</name>
</author>
<author><name sortKey="Orecchia, R" uniqKey="Orecchia R">R Orecchia</name>
</author>
<author><name sortKey="Luini, A" uniqKey="Luini A">A Luini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leong, C" uniqKey="Leong C">C Leong</name>
</author>
<author><name sortKey="Boyages, J" uniqKey="Boyages J">J Boyages</name>
</author>
<author><name sortKey="Jayasinghe, Uw" uniqKey="Jayasinghe U">UW Jayasinghe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sadek, Bt" uniqKey="Sadek B">BT Sadek</name>
</author>
<author><name sortKey="Homayounfar, G" uniqKey="Homayounfar G">G Homayounfar</name>
</author>
<author><name sortKey="Abi Raad, Rf" uniqKey="Abi Raad R">RF Abi Raad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garvey, Em" uniqKey="Garvey E">EM Garvey</name>
</author>
<author><name sortKey="Senior, Da" uniqKey="Senior D">DA Senior</name>
</author>
<author><name sortKey="Pockaj, Ba" uniqKey="Pockaj B">BA Pockaj</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bosma, Scj" uniqKey="Bosma S">SCJ Bosma</name>
</author>
<author><name sortKey="Van Der Leij, F" uniqKey="Van Der Leij F">F van der Leij</name>
</author>
<author><name sortKey="Van Werkhoven, E" uniqKey="Van Werkhoven E">E van Werkhoven</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moran, Ms" uniqKey="Moran M">MS Moran</name>
</author>
<author><name sortKey="Schnitt, Sj" uniqKey="Schnitt S">SJ Schnitt</name>
</author>
<author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Galimberti, V" uniqKey="Galimberti V">V Galimberti</name>
</author>
<author><name sortKey="Taffurelli, M" uniqKey="Taffurelli M">M Taffurelli</name>
</author>
<author><name sortKey="Leonardi, Mc" uniqKey="Leonardi M">MC Leonardi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deore, Sm" uniqKey="Deore S">SM Deore</name>
</author>
<author><name sortKey="Sarin, R" uniqKey="Sarin R">R Sarin</name>
</author>
<author><name sortKey="Dinshaw, Ka" uniqKey="Dinshaw K">KA Dinshaw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Budach, W" uniqKey="Budach W">W Budach</name>
</author>
<author><name sortKey="Bolke, E" uniqKey="Bolke E">E Bolke</name>
</author>
<author><name sortKey="Matuschek, C" uniqKey="Matuschek C">C Matuschek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Resch, A" uniqKey="Resch A">A Resch</name>
</author>
<author><name sortKey="Potter, R" uniqKey="Potter R">R Potter</name>
</author>
<author><name sortKey="Van Limbergen, E" uniqKey="Van Limbergen E">E Van Limbergen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ott, Oj" uniqKey="Ott O">OJ Ott</name>
</author>
<author><name sortKey="Schulz Wendtland, R" uniqKey="Schulz Wendtland R">R Schulz-Wendtland</name>
</author>
<author><name sortKey="Uter, W" uniqKey="Uter W">W Uter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gutierrez, C" uniqKey="Gutierrez C">C Gutiérrez</name>
</author>
<author><name sortKey="Najjari, D" uniqKey="Najjari D">D Najjari</name>
</author>
<author><name sortKey="Martinez, E" uniqKey="Martinez E">E Martinez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wazer, De" uniqKey="Wazer D">DE Wazer</name>
</author>
<author><name sortKey="Kaufman, S" uniqKey="Kaufman S">S Kaufman</name>
</author>
<author><name sortKey="Cuttino, L" uniqKey="Cuttino L">L Cuttino</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garsa, Aa" uniqKey="Garsa A">AA Garsa</name>
</author>
<author><name sortKey="Ferraro, Dj" uniqKey="Ferraro D">DJ Ferraro</name>
</author>
<author><name sortKey="Dewees, T" uniqKey="Dewees T">T DeWees</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vugts, G" uniqKey="Vugts G">G Vugts</name>
</author>
<author><name sortKey="Maaskant Braat, Aj" uniqKey="Maaskant Braat A">AJ Maaskant-Braat</name>
</author>
<author><name sortKey="Niewenhuijzen, Ga" uniqKey="Niewenhuijzen G">GA Niewenhuijzen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marchal, C" uniqKey="Marchal C">C Marchal</name>
</author>
<author><name sortKey="Weber, B" uniqKey="Weber B">B Weber</name>
</author>
<author><name sortKey="De Lafontan, B" uniqKey="De Lafontan B">B de Lafontan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grantzau, T" uniqKey="Grantzau T">T Grantzau</name>
</author>
<author><name sortKey="Overgaard, J" uniqKey="Overgaard J">J Overgaard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mery, Cm" uniqKey="Mery C">CM Mery</name>
</author>
<author><name sortKey="George, S" uniqKey="George S">S George</name>
</author>
<author><name sortKey="Bertagnolli, Mm" uniqKey="Bertagnolli M">MM Bertagnolli</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Pologne</li>
</country>
</list>
<tree><noCountry><name sortKey="Dziadziuszko, Rafal" sort="Dziadziuszko, Rafal" uniqKey="Dziadziuszko R" first="Rafał" last="Dziadziuszko">Rafał Dziadziuszko</name>
<name sortKey="Jassem, Jacek" sort="Jassem, Jacek" uniqKey="Jassem J" first="Jacek" last="Jassem">Jacek Jassem</name>
<name sortKey="Serkies, Krystyna" sort="Serkies, Krystyna" uniqKey="Serkies K" first="Krystyna" last="Serkies">Krystyna Serkies</name>
</noCountry>
<country name="Pologne"><noRegion><name sortKey="Ja Kiewicz, Janusz" sort="Ja Kiewicz, Janusz" uniqKey="Ja Kiewicz J" first="Janusz" last="Ja Kiewicz">Janusz Ja Kiewicz</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C13 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C13 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:5241379 |texte= Pulsed-dose-rate peri-operative brachytherapy as an interstitial boost in organ-sparing treatment of breast cancer }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28115954" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |